Morphofunctional and Metabolic Alterations after Orchiectomy

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Morphofunctional and Metabolic Alterations after Orchiectomy

Methods: Young and adult male Wistar rats were distributed into the following groups: Group 1 – control, animals submitted only to scrotal incision and suture. Group 2 – animals submitted to total bilateral epididymectomy and orchiectomy. After these operations, studies were carried out to analyze possible repercussions of hypogonadism. In Study A, serum levels of free testosterone were measure...

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Mercury (Hg) is a global pollutant that may exert its toxic effects on living organisms and is found in both aquatic and terrestrial ecosystems in three chemical forms; elemental, organic, and inorganic. The inorganic form (iHg) tends to predominantly accumulate in aquatic environments. The gill apparatus is a very dynamic organ that plays a fundamental role in gas exchange, osmoregulation, aci...

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Transwomen and the Metabolic Syndrome: Is Orchiectomy Protective?

Background: Male-to-female transsexual women or transwomen who undergo cross-sex hormone treatments experience increased health-related risks (e.g., increased rates of cardiovascular disease and premature death). Yet, the exact mechanism by which altering biochemistry leads to metabolic impairment remains unclear. While much attention has been paid to cross-sex hormone therapy, little is known ...

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Morphofunctional renal alterations in rats induced by intrauterine hyperglycemic environment

INTRODUCTION The renal development of rats begins in intrauterine life, finishing by 15 days after birth. Diabetes and other diseases during pregnancy can cause systemic changes in the offspring. We evaluated the structural and functional renal alterations of the offspring from diabetic mothers. MATERIAL AND METHODS Pregnant rats were separated and 1, 7, 30 and 90 days-old (DO) pups were divi...

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Androgen deprivation therapy through bilateral orchiectomy: increased metabolic risks.

Prostate cancer is one of the most common malignancies in men. Previous research has determined that androgen deprivation therapy (ADT) may be accompanied by an unfavourable metabolic profile. In this prospective study, 133 men were recruited, including 46 prostate cancer patients who had undergone bilateral orchiectomy and been on flutamide (the ADT group), 37 men with prostate cancer who had ...

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ژورنال

عنوان ژورنال: Open Journal of Biological Sciences

سال: 2016

ISSN: 2640-7795

DOI: 10.17352/ojbs.000001